Science for Education Today, 2019, vol. 9, no. 1, pp. 208–225
© Kozlova A. P., Koroshchenko G. A., Lomovskiy I. O., Golovin M. S., Gordeeva E. I., Nedovesova S. A., Aizman R. I., 2019
UDC: 
591.133+591.149.2

Prevention and correction of carbohydrate metabolism disorders in diabetes mellitus as a medical and social problem of building a healthy lifestyle: An experimental rationale

Kozlova A. P. 1 (Novosibirsk, Russian Federation), Koroshchenko G. A. 1 (Novosibirsk, Russian Federation), Lomovskiy I. O. 2 (Novosibirsk, Russian Federation), Golovin M. S. 1 (Novosibirsk, Russian Federation), Gordeeva E. I. 1 (Novosibirsk, Russian Federation), Nedovesova S. A. 1 (Novosibirsk, Russian Federation), Aizman R. I. 1 (Novosibirsk, Russian Federation)
1 Novosibirsk State Pedagogical University
2 Institute of Solid State Chemistry and Mechanochemistry Siberian Branch of the Russian Academy of Sciences
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Abstract: 

Introduction. Currently, diabetes is a serious medical and social problem for national security of all countries due to the progressive increase in morbidity and mortality. Unhealthy lifestyle, characterized by wrong diet, low physical activity and mental stress is considered as one of the leading causes of diabetes, especially type II. In this regard, promoting healthy behavior can contribute to prevention and correction of carbohydrate metabolism disorders. Various food (dietary) supplements, having beneficial biological effect, can be considered as components of a healthy diet.
The aim of this research was to study the mechanism of action of such food supplements as Curcuma longa rhizomes and the powder of Galega orientalis for experimental justification of their use in healthy nutrition and correction of carbohydrate metabolism disorders in diabetes mellitus.
Materials and methods. The study was conducted in adult male Wistar rats. All animals were divided into 4 groups: a control one and three groups of rats with an experimental alloxan-induced model of diabetes mellitus (DM). Animals of the 1-st and the 2-nd groups were kept on standard diet, while rats of the 3-rd and the 4-th groups were fed turmeric powder or Galega (2 per cent of the feed). During the observation, the blood glucose concentration was measured (using the method of electrochemical enzymatic analysis). At the end of the experiment, the researchers measured insulin and corticosterone concentrations by ELISA method; blood biochemical parameters (using an automatic analyzer); and liver glycogen content (using the Schick reaction according to MacManus). Herbal preparations were produced by mechanochemical method on the basis of Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Science.
Results. It has been established that intake of Curcuma longa in rats with diabetes, compared to animals that consumed standard feed and feed with Galega orientalis powder, caused a less pronounced increase in blood glucose concentration due to increased insulin concentration and lower plasma corticosterone concentration and glycogen accumulation in the liver. Intake of both herbal preparations also contributed to the improvement of lipid and protein metabolism, such as triglycerides, creatinine and urea, whereas more pronounced metabolic disorders’ of all types of metabolism were observed in experimental animals of the second group 2.
Conclusions. The obtained results substantiate using food supplements containing Curcuma longa rhizome and, to a lesser extent, Galega orientalis for correction of carbohydrate, protein and fat metabolism in diabetes and, consequently, adding them to the diet as a component of healthy nutrition for prevention of carbohydrate metabolism disorders.

Keywords: 

Diabetes mellitus; Metabolism; Food supplements; Turmeric; Galega; Lifestyle; Medical and social problem.

URL WoS/RSCI: https://www.webofscience.com/wos/rsci/full-record/RSCI:38165993

Prominence Percentile SciVal: 61.126 Insulin Replacement Therapy | Hemoglobin A1C | Non Insulin Dependent Diabetes Mellitus

URL SCOPUS: https://www.scopus.com/record/display.uri?eid=2-s2.0-85065102287&origin=...

Prevention and correction of carbohydrate metabolism disorders in diabetes mellitus as a medical and social problem of building a healthy lifestyle: An experimental rationale

 

 

For citation:
Kozlova A. P., Koroshchenko G. A., Lomovskiy I. O., Golovin M. S., Gordeeva E. I., Nedovesova S. A., Aizman R. I. Prevention and correction of carbohydrate metabolism disorders in diabetes mellitus as a medical and social problem of building a healthy lifestyle: An experimental rationale. Science for Education Today, 2019, vol. 9, no. 1, pp. 208–225. DOI: http://dx.doi.org/10.15293/2658-6762.1901.13
References: 
  1. Ametov A. S. The level of glycated hemoglobin as a significant marker of high-grade glycemic control and a predictor of late vascular complications of diabetes mellitus type 2. Russian Medical Journal, 2011, vol. 19 (13), pp. 832–837. (In Russian) URL: https://elibrary.ru/item.asp?id=20168668
  2. Vengerovskii A. I., Yakimova T. V., Nasanova O. N. Influence of medicinal plant extracts on the functions and antioxidant protection of erythrocytes in rats with experimental diabetes mellitus. Experimental and Clinical Pharmacology, 2016, vol. 79 (2), pp. 29–33. (In Russian) URL: https://elibrary.ru/item.asp?id=25795273
  3. Gavrovskaya L. K., Ryzhova O. V., Safonova A. F., Aleksandrova I. Ya., Sapronov N. S. Effect of taurine and thioctacide on carbohydrate metabolism and antioxydant system in rats with experimental diabetes. Experimental and Clinical Pharmacology, 2008, vol. 71 (3), pp. 34–35. (In Russian) DOI: http://dx.doi.org/10.30906/0869-2092-2008-71-3-34-35
  4. Dedov I. I., Kalashnikova M. F., Belousov D. Y., Kolbin A. S., Rafalskiy V. V., Cheberda A. E., Kantemirova M. A., Zakiev V. D., Fadeyev V. V. Cost-of-Illness Analysis of Type 2 Diabetes mellitus in the Russian Federation: Results from Russian multicenter observational pharmacoepidemiologic study of diabetes care for patients with type 2 diabetes mellitus (FORSIGHT-Т2DM). Diabetes Mellitus, 2017, vol. 20 (6), pp. 403–419. (In Russian) DOI: https://doi.org/10.14341/DM9278
  5. Dedov I. I., Shestakova M. V., Vikulova O. K., Zheleznyakova A. V., Isakov M. A. Diabetes mellitus in Russian Federation: Prevalence, morbidity, mortality, parameters of glycaemic control and structure of glucose lowering therapy according to the federal diabetes register, status 2017. Diabetes Mellitus, 2018, vol. 21 (3), pp. 144–159. (In Russian) DOI: http://dx.doi.org/10.14341/DM9686
  6. Dedov I. I., Shestakova M. V., Vikulova O. K. Epidemiology of diabetes mellitus in Russian Federation: clinical and statistical report according to the federal diabetes registry. Diabetes Mellitus, 2017, vol. 20 (1), pp. 13–41. (In Russian) DOI: http://dx.doi.org/10.14341/DM8664
  7. Kozlova A. P., Koroshchenko G. A., Aizman R. I. What components of plant curcuma longa provide hypoglycemic effect in diabetes mellitus? Novosibirsk State Pedagogical University Bulletin, 2016, vol. 6 (3), pp. 167–175. (In Russian) DOI: http://dx.doi.org/10.15293/2226-3365.1603.15
  8. Koroshchenko G. A., Subotyalov M. A., Gerasev A. D., Aisman R. I. Influence of a rhizome of plant curcuma longa on a carbohydrate balance in experiments on rats. Bulletin of Siberian Branch of Russian Academy of Medical Sciences, 2011, vol. 31 (3), pp. 92–96. (In Russian) URL: https://elibrary.ru/item.asp?id=17752589  
  9. Mikhaylichenko V. Yu., Stolyarov S. S. Role of insular and contra-insular hormones in the pathogenesis of alloxan diabetes in rats in the experiment. Modern Problems of Science and Education, 2015, no. 4, pp. 485. (In Russian) URL: https://elibrary.ru/item.asp?id=23940326
  10. Mikhailichenko V. Yu., Pilipchuk A. A. Pathophysiological features of the heart in rats with experimental diabetes mellitus complicated by myocardial infarction. Crimea Journal of Experimental and Clinical Medicine, 2017, vol. 7 (1), pp. 27–37. (In Russian) URL: https://elibrary.ru/item.asp?id=28840222
  11. Ostanova N. A., Prjakhina N. I. Some pharmacological properties of above-ground part of galega Officinalis L. and G. Orientalis Lam. Rastitelnye Resursy, 2003, vol. 39 (4), pp. 119–129. (In Russian) URL: https://elibrary.ru/item.asp?id=17080783
  12. Sogujko Y. R., Krivko Y. Y., Krikun Е. N., Novikov О. О. Morphofunctional characteristics of rat liver in norm and diabetes in experiment. Modern Problems of Science and Education, 2013, no. 1, pp. 52. (In Russian) URL: https://elibrary.ru/item.asp?id=18828985
  13. Tutelyan V. A., Kiseleva T. L., Kochetkova A. A., Smirnova E. A., Kiseleva M. A., Sarkisyan V. A. Promising source of micronutrients for specialized foods with modified carbohydrate profile: traditional medicine experience. Problems of Nutrition, 2016, vol. 85 (4), pp. 46–60. (In Russian) URL: https://elibrary.ru/item.asp?id=26486692
  14. Truhacheva N. V. Mathematical statistics in biomedical research using the Statistica package. Moscow, GEOTAR-Media Publ., 2012, 384 p. (In Russian) URL: https://elibrary.ru/item.asp?id=19561247
  15. Chernyavskaya I. V., Zakharova A. A., Romanova I. P., Kravchun N. A. Phytotherapy in the complex treatment of type 2 diabetes mellitus in combination with non-alcoholic fatty liver disease. News of Medicine and Pharmacy, 2014, no. 20, pp. 18–19_m. (In Russian) URL: https://elibrary.ru/item.asp?id=23147651
  16. Yakimova T. V., Ukhova T. M., Burkova V. N., Arbuzov A. G., Mozzhelina T. K., Saratikov A. S. Hypoglycemic effect of the extract from Galega Officinalis (Fabaceae), cultivated in Altai. Rastitelnye Resursy, 2005, vol. 41 (2), pp. 134–138. (In Russian) URL: https://elibrary.ru/item.asp?id=9150200
  17. Aguiar E. J., Morgan P. J., Collins C. E., Plotnikoff R. C., Young M. D., Callister R. Efficacy of the type 2 diabetes prevention using lifestyle education program RCT. American Journal of Preventive Medicine, 2016, vol. 50 (3), pp. 353–364. DOI: http://dx.doi.org/10.1016/j.amepre.2015.08.020
  18. Aizman R. I., Koroshchenko G. A., Gajdarova A. P., Lukanina S. N., Subotyalov M. A. The Mechanisms of PLANT rhizome curcuma longa action on carbohydrate metabolism in
    alloxan – induced diabetes mellitus rats. American Journal of Biomedical Research, 2015, vol.  3, issue  1, pp. 1–5. DOI: http://dx.doi.org/10.12691/ajbr-3-1-1 URL: http://www.sciepub.com/ajbr/abstract/3936
  19. Babu P. S., Srinivasan K. Hypolipidemic action оf curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Molecular and Cellular Biochemistry, 1997, vol. 166, issue 1-2, pp. 169–175. DOI: http://dx.doi.org/10.1023/A:1006819605211
  20. Christensen K. B., Minet A., Svenstrup H., Grevsen K., Zhang H., Schrader E., Rimbach G., Wein S., Wolffram S., Kristiansen K., Christensen L. P. Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake. Phytotherapy Research, 2009, vol. 23, issue 9, pp. 1316–1325. DOI: http://dx.doi.org/10.1002/ptr.2782
  21. Chuengsamarn S., Rattanamongkolgul S., Luechapudiporn R., Phisalaphong C., Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 2012, vol. 35 (11), pp. 2121–2127. DOI: http://dx.doi.org/10.2337/dc12-0116
  22. Coxon G. D., Furman B. L., Harvey A. L., McTavish J., Mooney M. H., Arastoo M., Kennedy A. R., Tettey J. M., Waigh R. D. Benzylguanidines and other galegine analogues inducing weight loss in mice. Journal of Мedicinal Сhemistry, 2009, vol. 52, issue 11, pp. 3457–3463. DOI: http://dx.doi.org/10.1021/jm8011933
  23. Ford C. N., Weber M. B., Staimez L. R., Anjana R. M., Lakshmi K., Mohan V., Narayan K. M. V., Harish R. Dietary changes in a diabetes prevention intervention among people with prediabetes: the Diabetes Community Lifestyle Improvement Program trial. Acta Diabetologiсa, 2018. Online First. DOI: http://dx.doi.org/10.1007/s00592-018-1249-1
  24. Gârgavu S. R., Clenciu D., Rosu M. M., Tenea-Cojan T. S., Costache A., Vladu I. M., Mota M. The assessment of life style and the visceral adiposity index as cardiometabolic risk factors. Arch Balk Med Union, 2018, vol. 53 (2), pp. 189–195. DOI: http://dx.doi.org/10.31688/ABMU.2018.53.2.02
  25. Goswami K., Gandhe M. Evolution of metabolic syndrome and its biomarkers. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 2018, vol. 12, issue 6, pp. 1071–1074. DOI: http://dx.doi.org/10.1016/j.dsx.2018.06.027
  26. Jiménez-Osorio A. S., Monroy A., Alavez S. Curcumin and insulin resistance – Molecular targets and clinical evidences. Biofactors, 2016, vol. 42, issue 6, pp. 561–580. DOI: http://dx.doi.org/10.1002/biof.1302
  27. Korzeniowska K., Derkowska I., Zalinska M., Remesz A., Kmiec A., Mysliwiec M. Changes in diet and lifestyle may lower the risk of type 1 diabetes mellitus in children-environmental factors influencing type 1 diabetes mellitus morbidity.Journal of Diabetes and Metabolism, 2016, vol. 7, pp. 716. DOI: http://dx.doi.org/10.4172/2155-6156.1000716
  28. Ley S. H., Hamdy O., Mohan V., Hu F. B. Prevention and management of type 2 diabetes: dietary components and nutritional strategies. Lancet, 2014, vol. 383, issue 9933, pp. 1999–2007. DOI: http://dx.doi.org/10.1016/S0140-6736(14)60613-9
  29. Lui T. N., Tsao C. W., Huang S. Y., Chang C. H., Cheng J. T. Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells. Neuroscience letters, 2010, vol. 474, issue 3, pp. 144–147. DOI: http://dx.doi.org/10.1016/j.neulet.2010.03.024
  30. Lupak M. I. Khokhla M. R., Hachkova G. Ya., Kanyuka O. P., Klymyshyn N. I., Chajka Ya. P., Skybitska M. I., Sybirna N. O. The alkaloid-free fraction from Galega officinalis extract prevents oxidative stress under experimental diabetes mellitus. Ukrainian Biochemical Journal, 2015, vol. 87, issue 4, pp. 78–86. DOI: http://dx.doi.org/10.15407/ubj87.04.078
  31. Newman D. J., Cragg G. M. Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products, 2016, vol. 79, issue 3, pp. 629–661. DOI: http://dx.doi.org/10.1021/acs.jnatprod.5b01055
  32. Newman D. J., Cragg G. M., Snader K. M. The influence of natural products upon drug discovery. Natural Product Reports, 2000, vol. 17, issue 3, pp. 215–234. DOI: http://dx.doi.org/10.1039/A902202 PMID: 10888010
  33. Meenu V., Gayathry M. S., Gisna J., Shalini S. D., Roshni P. R., Remya R. A study on comorbidities and life style associated with diabetes patients. International Research Journal of Pharmacy, 2013, vol. 4 (5), pp. 148–149. DOI: http://dx.doi.org/10.7897/2230-8407.04530
  34. Mooney M. H., Fogarty S., Stevenson C., Gallagher A. M., Palit P., Hawley S. A., Hardie D. G., Coxon G. D., Waigh R. D., Tate R. J., Harvey A. L., Furman B. L. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. British Journal of Pharmacology, 2008, vol. 153, issue 8, pp. 1669–1677. DOI: http://dx.doi.org/10.1038/bjp.2008.37
  35. Mousavi S. M., Milajerdi A., Varkaneh H. K., Gorjipour M. M., Esmaillzadeh A. The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Critical Review of Food Science and Nutrition, 2018. Latest Articles. DOI: http://dx.doi.org/10.1080/10408398.2018.1517724
  36. Pereira M. G. Beyond life style interventions in type 2 diabetes. Revista Latino-Americana de Enfermagem, 2016, vol. 24, pp. e2765. DOI: http://dx.doi.org/10.1590/1518-8345.0000.2765
  37. Slentz C. A., Bateman L. A., Willis L. H., Granville E. O., Piner L. W., Samsa G. P., Setji T. L., Muehlbauer M. J., Huffman K. M., Bales C. W., Kraus W. E. Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial. Diabetologia, 2016, vol. 59 (10), pp. 2088–2098. DOI: http://dx.doi.org/10.1007/s00125-016-4051-z
  38. Subramaniam S., Dhillon J. S., Ahmad M. S., Leong J. W. S, Teoh C., Huang C. S. Eliciting user requirements to design a prediabetes self-care application: A focus group study with prediabetics and diabetics. Indian Journal of Science and Technology, 2016, vol. 9, special issue 1, pp. 1–8. DOI: 10.17485/ijst/2016/v9iS1/106819
  39. Xi P., Liu R. H. Whole food approach for type 2 diabetes prevention. Molecular Nutrition and Food Research, 2016, vol. 60 (8), pp. 1819–1836. DOI: http://dx.doi.org/10.1002/mnfr.201500963
  40. Yan C., Zhang Y., Zhang X., Aa J., Wang G., Xie Y. Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice. Biomedical and Pharmacotherapy, 2018, vol. 105, pp. 274–281. DOI: http://dx.doi.org/10.1016/j.biopha.2018.05.135
  41. Zhang H., Wei J., Xue R., Wu J. D., Zhao W., Wang Z. Z., Wang S. K., Zhou Z. X., Song D. Q., Wang Y. M., Pan H. N., Kong W. J., Jiang J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism, 2010, vol. 59 (2), p. 285–292. DOI: http://dx.doi.org/ 10.1016/j.metabol.2009.07.029
  42. Zhang Z., Li K. Curcumin attenuates high glucose-induced inflammatory injury through the reactive oxygen species-phosphoinositide 3-kinase/protein kinase B-nuclear factor-κB signaling pathway in rat thoracic aorta endothelial cells. Journal of Diabetes Investigation, 2018, vol. 9 (4), pp. 731–740. DOI: http://dx.doi.org/10.1111/jdi.12767
Date of the publication 28.02.2019