Novosibirsk State Pedagogical University Bulletin, 2013, vol. 3, no. 5, pp. 101–110
© Panin L. E., Mokrushnikov P. V., 2013
UDC: 
538.9: 577.352.332/.335: 577.175.5: 577.31

Effects of synthetic vitamin E derivative on the rheological properties of red blood cell membranes

Panin L. E. 1 (Novosibirsk, Russian Federation), Mokrushnikov P. V. 1 (Novosibirsk, Russian Federation)
1 State Research Institute of Biochemistry
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Abstract: 

Methods of the fluorescent analysis investigated action of derivatives of vitamin E tiofan and tiofan-M on rheological properties of membranes of erythrocytes. The first formulation reduced the microviscosity of a lipid-lipid, and protein-lipid interactions. The second drug is reduced microviscosity of the protein-lipid interactions, and increased in the area of lipid-lipid interactions. Checking the effectiveness of antioxidant erythrocyte membranes showed that thiophane significantly inhibits peroxidation of membrane lipids and the formation of lipid-protein cross-links, restoring the rheological properties of red blood cells. This drug is recommended by us to prevent lipid peroxidation in persons working in Arctic conditions.

Keywords: 

microviscosity of membranes, lipoperoxidation, tiofan

For citation:
Panin L. E., Mokrushnikov P. V. Effects of synthetic vitamin E derivative on the rheological properties of red blood cell membranes. Novosibirsk State Pedagogical University Bulletin, 2013, vol. 3, no. 5, pp. 101–110.
References: 

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Date of the publication 26.10.2013