Novosibirsk State Pedagogical University Bulletin, 2018, No.1, pp.223-238

The study of the effectiveness of combined use of Cortexin and physical exercises in optimization of the functional system of human statokinetic stability

Sorokina L. 1 (St.Petersburg, Russian Federation), Buynov L. 2 (St.Petersburg, Russian Federation), Plakhov N. N. 2 (Saint-Petersburg, Russian Federation), Aizman R. 3 (Novosibirsk, Russian Federation)
1 Herzen state pedagogocal university of Russia
2 Herzen state pedagogical univercity of Russia
3 Novosibirsk state pedagogical unuversity

Introduction. Fundamental and applied research in the field of optimization of the functional system of human statokinetic stability to date is one of the leading positions in the Russian and world physiology of work. The aim of the research is to study the effectiveness of the course using of a peptide bioregulator Cortexin in combination with physical exercises with the help of a modified test by A. I. Yarotsky in increasing of human statokinetic stability.
Materials and Methods. The sample consisted of 28 healthy male subjects aged between 20 and 22 years. (The experimental group included 17 subjects, the control group consisted of 11 subjects). The method of continuous cumulation of Coriolis accelerations (CCCA) was used in order to stimulate the vestibular apparatus in the experimental group. To increase statokinetic stability, cortexin was used in combination with active training with the help of a modified test by A. I. Yarotsky (MTY).
Results. It is shown that the subjects of the experimental group treated with Cortexin in combination with MTY demonstrated increased time of CCCA. Simultaneously, decrease in the severity of vestibulosensory, vestibulovegetative, and vestibulosomatic reactions was observed which indicated the improvement of subjects’ statokinetic tolerance in the experimental group in the test CCCA. Positive dynamics of indicators in the experimental group was confirmed by the data of the static stabilometric test in the integrated functional computer stabilography. Thus, tests with open and closed eyes showed marked decrease in the rate of increase in the length and area of statokinesigram, oscillation amplitude (OA), and projection of the total center of gravity (PTCG) in the frontal and sagittal planes, and the coefficient of asymmetry (CA) in the frontal and sagittal directions.
Conclusions. The obtained results allow to recommend using a peptide bioregulator Cortexin in combination with physical exercises to stimulate the human vestibular apparatus and improve statokinetic stability.


Statokinetic stability; Computer stabilography; Functional status; Professional performance; Cortexin

  1. Blaguinin A. A., Sinelnikov S. N., Liashedko S. P. State-Of-The-Art and Problems of Spatial Orientation Training of Pilots. Aerospace and Environmental Medicine, 2017, vol. 51, no. 1, pp. 65–69. (In Russian) DOI:
  2. Blaginin A. A., Lizogub I. N. Medical Aspects of Flight Safety. Military Medical Journal, 2017, vol. 338, no. 4, pp. 51–55. (In Russian) URL:
  3. Blaginin A. A., Sinelnikov S. N., Prishchepin B. I., Kudryakov S. A., Shevelko A. A., Yachmeneva P. M. Psychophysiological methods to support pilots training in the flight simulator. Military Medical Journal, 2016, vol. 337, no. 11, pp. 49–54. (In Russian) URL:
  4. Blaginin A. A., Kotov O. V., Zhiltsova I. I., Annenkov O. A., Syroezhkin F. A. Possibilities of computer stabilography as a part of evaluation of functional state of aerospace operator’s organism. Military Medical Journal, 2016, vol. 337, no. 8, pp. 51–57. (In Russian) URL:
  5. Blaginin A. A., Grebenyuk A. N., Lizogub I. N.  The main ways of improvemnt of medical support of the Air Forces in modern conditions. Military Medical Journal, 2014, vol. 335, no. 2, pp. 42–45. (In Russian) URL:    
  6. Blaginin A. A., Sinelnikov S. N., Smolyaninova S. V.        Evaluation of the functional state of operators with allowance for individual psychological characteristics. Human Physiology, 2017, vol. 43, no. 1, pp. 11–17. (In Russian) DOI:  
  7. Boldyreva G. N., Sharova E. V., Zhavoronkova L. A., Celapena M. V., Dubrovskaya L. P., Simonova O. A., Fadeyeva L. M., Pronin I. N., Kornienko V. N. Structural and functional features of the brain when performing and reporting physical activity in healthy people (electroencephalogram and functional magnetic resonance imaging studies). Journal of Higher Nervous Activity Them. I. P. Pavlov, 2013, vol. 63, no. 3, pp. 316. (In Russian) DOI:
  8. Glaznikov L. A., Buĭnov L. G., Govorun M. I., Sorokina L. A., Nigmedzianov R. A., Golovanov A. E.  The pathogenetic approach to the development of tools and methods for the improvement of statokinetic stability in the operators of aerospace systems. Bulletin of Otorhinolaryngology, 2012, no. 4, pp. 33–36. (In Russian) URL:  
  9. Glaznikov L. A., Blaguinin A. A., Sorokina L. A., Buynov L. G., Syroezhkin F. A., Nigmedzianov R. A., Plakhov N. N., Kotov O. V. Studies of Effectiveness of Electrical Tranquilization of the Central Nervous System in Combination with Vestibular Training for Improvement of Statokinetic Stability. Aerospace and Environmental Medicine, 2017, vol. 51, no. 3, pp. 31–38. (In Russian) DOI:  
  10. Zaĭtseva O. V.  Examination and rehabilitation of patients with peripheric vestibular vertigo. Bulletin of Otorhinolaryngology, 2010, no. 6, pp. 44–47. (In Russian) URL:  
  11. Zamergrad M. V. Vestibular Rehabilitation. Neurology, Neuropsychiatry, Psychosomatics, 2009, no. 2, pp. 19–22. (In Russian) URL:  
  12. Zamergrad M. V. Rehabilitation in vestibular system diseases. Neurology, Neuropsychiatry, Psychosomatics, 2013, no. 1, pp. 18–22. (In Russian) URL:
  13. Zamergrad M. V., Parfenov V. A., Yakhno N. N. Optimal duration of therapy in the recovery period of vestibular diseases. Neurology, Neuropsychiatry, Psychosomatics, 2014, vol. 6 (3), pp. 10–16. (In Russian) DOI:  
  14. Kozlovskaya I. B. Gravity and the Tonic Postural Motor System. Aerospace and Environmental Medicine, 2017, vol. 51, no. 3, pp. 5–21. (In Russian) DOI:  
  15. Kunelskaya N. L., Baibakova E. V., Chugunova M. A., Guseva A. L. Vestibular Rehabilitation Therapy in Patients with Vestibular Disorders. General Medicine, 2015, no. 2, pp. 52–55. (In Russian) URL:  
  16. Palchun V. T., Guseva A. L., Chistov S. D. Vestibular rehabilitation: substantiation, indications, application. Consilium Medicum, 2015, vol. 17, no. 9, pp. 113–120. (In Russian) URL:  
  17. Plakhov N. N., Buynov L. G., Makarova L. P.  Functional State of Seamen Operators in Sea Voyage. Hygiene and Sanitation, 2017, vol. 96, no. 3, pp. 261–264. (In Russian) URL:
  18. Rukavishnikov I. V., Amirova L. E., Kukoba T. B., Tomilovskaya E. S., Kozlovskaya I. B. Effects of Gravitational Unloading on Back Muscles Tone. Human Physiology, 2017, vol. 43, no. 3, pp. 64–73. (In Russian) URL:
  19. Syroezhkin F. A., Dvoryachikov V. V., Blaginin A. A., Bujnov L. G. Modern means of vestibular rehabilitation and the increase statokinetic sustainability. Military Medical Journal, 2016, vol. 337, no. 4, pp. 36–42. (In Russian) URL:  
  20. Suhoterin A. F., Pashenko P. S., Plahov N. N., Zhuravlev A. G. Sympathoadrenomedullary role in the formation of adaptation pilots to the flight load. Aerospace and Environmental Medicine, 2015, vol. 49, no. 5, pp. 49–53. (In Russian) URL:  
  21. Usachev V. I., Govorun M. I., Golovanov A. E., Kuznetsov M. S. Dynamic stabilization the vertical position of the human body. Proceedings of the SFU. Technical Science, 2010, no. 9, pp. 164–169. (In Russian) URL:
  22. Alpini D. C., Cesarani A., Brugnoni G. Vertigo rehabilitation protocols. New-York, Springer Publ., 2014, 244 p. DOI:  
  23. Bukhtiyarov I. V., Chistov S. D., Ponomarenko K. V., Rybachenko T. A. Interocular nystagmus asymmetry and motion sickness. Human Physiology, 2014, vol. 40, no. 7, pp. 718–722. DOI:  
  24. Golovin M. S., Aizman R. I. Аudiovisual stimulation modulates physical performance and biochemical and hormonal status of athletes. Bulletin of Experimental Biology and Medicine, 2016, vol. 161, no. 5, pp. 638–642. DOI:  
  25. Herdman S. J., Hall C. D., Delaune W. Variables associated with outcome in patients with unilateral vestibular hypofunction. Neurorehabilitation and Neural Repair, 2012, vol. 26, no. 2, pp. 151–162. DOI:  
  26. Hallgren E., Kornilova L., Fransen E., Glukhikh D., Moore S. T., Clément G., Van Ombergen A., MacDougall H., Naumov I., Wuyts F. L. Decreased otolith-mediated vestibular response in 25 astronauts induced by long-duration spaceflight. Journal of Neurophysiology, 2016, vol. 115,  no. 6,  pp. 3045–3051. DOI:  
  27. Hallgren E., Migeotte P.-F., Kornilova L., Delière Q., Fransen E., Glukhikh D., Moore S. T., Clément G., Diedrich A., MacDougall H., Wuyts F. L. Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space. Scientific Reports, 2015, vol. 5, article number 17627. DOI:  
  28. Kubryak O., Guseva A., Grohovsky S. Static motor-cognitive test and evaluation criteria in the management of treatment. International Journal of Psychophysiology, 2012, vol. 85, no. 3, pp. 383–385. URL:  
  29. Kornilova L. N., Naumov I. A., Makarova S. Static torsional otolith-cervical-ocular reflex after prolonged exposure to weightlessness and a 7-day immersion. Acta Astronautica, 2011, vol. 68,  no. 9-10,  pp. 1462–1468. DOI:  
  30. Kornilova L. N., Naumov I. A., Glukhikh D. O., Habarova E. V., Kozlovskaya I. B. The effects of support-proprioceptive deprivation on visual-manual tracking and vestibular function. Human Physiology, 2013, vol. 39, no. 5, pp. 462–471. DOI:  
  31. Mao Y., Chen P., Li L., Huang D. Virtual reality training improves balance function. Neural Regeneration Research, 2014, vol. 9, no. 17, pp. 1628–1634. DOI:  
  32. Morozova S. V., Alekseeva N. S., Lilenko S. V., Matsnev E. I., Melnikov O. A. Hughes P. Effects and safety profile of betahistine in patients in the russian contingent of osvald, an open-label observational study in vestibular vertigo. International Journal of General Medicine, 2015, vol. 8, pp. 47–53. DOI:  
  33. Nishiike S., Okazaki S., Watanabe H., Akizuki H., Imai T., Uno A., Kitahara T., Horii A., Takeda N., Inohara H. The effect of visual-vestibulosomatosensory conflict induced by virtual reality on postural stability in humans. Journal of Medical Investigation, 2013, vol. 60, no. 3-4, pp. 236–239.  DOI:  
  34. Nyberg L., Lundin-Olsson L., Sondell B., Backman A., Holmlund K., Eriksson S., Stenvall M., Rosendahl E., Maxhall M., Bucht G. Using a virtual reality system to study balance and walking in a virtual outdoor environment: a pilot study. Cyberpsychology and Behavior, 2006, vol. 9, no. 4, pp. 388–395.DOI:  
  35. Ohyama S., Nishiike S., Watanabe H., Matsuoka K., Akizuki H., Takeda N., Harada T. Autonomic responses during motion sickness induced by virtual reality. Auris Nasus Larynx, 2007, vol. 34, no. 3, pp. 303–306. DOI:  
  36. Parfenov V. A., Golyk V. A., Matsnev E. I., Morozova S. V., Melnikov O. A., Antonenko L. M., Sigaleva E. E., Situkho M. I., Asaulenko O. I., Popovych V. I., Zamergrad M. V. Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: the virtuoso study. PLoS ONE, 2017, vol. 12, no. 3, pp. e0174114. DOI:  
  37. Sayenko D. G., Miller T. F., Melnik K. A., Netreba A. I., Khusnutdinova D. R., Kitov V. V., Tomilovskaya E. S., Reschke M. F., Gerasimenko Y. P., Kozlovskaya I. B. Acute effects of dry immersion on kinematic characteristics of postural corrective responses. Acta Astronautica, 2016, vol. 121, pp. 110–115. DOI:  
  38. Sayenko D. G., Artamonov A. A., Kozlovskaya I. B. Characteristics of postural corrective responses before and after long-term spaceflights. Human Physiology, 2011, vol. 37, no. 5, pp. 594–601.  
  39. Van Ombergen A., Demertzi A., Tomilovskaya E., Jeurissen B., Sijbers J., Kozlovskaya I. B., Parizel P. M., Van de Heyning P. H., Sunaert S., Laureys S., Wuyts F. L. The effect of spaceflight and microgravity on the human brain. Journal of Neurology, 2017, vol. 264, suppl. 1, pp. 18–22. DOI:  
  40. Villard S. J., Flanagan M. B., Albanese G., Stoffregen T. A. Postural instability and motion sickness in a virtual moving room. Human Factors: Journal of the Human Factors and Ergonomics Society, 2008, vol. 50, no. 2, pp. 332–345. DOI:  
Date of the publication 28.02.2018